SALIVARY THE LEVEL OF PROINFLAMMATORY CYTOKINES IN CHILDREN WITH AUTOIMMUNE DIABETES MELLITUS IN DIFFERENT PHASES OF COMPENSATION ENDOCRINOPATHY

Aim. To assess the dynamics of the level of proinflammatory cytokines and their receptors in mixed saliva in patients with autoimmune diabetes mellitus during the period of the occlusal occlusion at various stages of disease compensation and to determine the possibility of applying these values in the early diagnosis and control of the effectiveness of endocrinopathy.

Materials and methods. The material of laboratory-diagnostic and clinical studies was the results of examination of 93 children during the period of the change of occlusion, which were divided into two groups. The comparison group consisted of children without endocrine pathology. The main group consisted of children diagnosed with type 1 diabetes mellitus, which were divided into two subgroups depending on the degree of endocrinopathy compensation. The level of pro-inflammatory cytokines and their receptors in the unstimulated oral liquid was carried out by the solid-phase enzyme-linked immunosorbent assay using the «Vector-Best»» and «Cytokine» reagent kits.

Results. With the compensated form of autoimmune diabetes mellitus, there is an overregulation of regulatory mechanisms with an imbalance in the level of soluble receptors initiating the realization of the proinflammatory properties of these cytokines. The decompensated form of autoimmune diabetes is caused by an absolute increase in virtually all pro-inflammatory cytokines in the oral fluid, with an even more pronounced imbalance in their soluble receptors.

Conclusion. In parallel with the therapeutic measures concerning the underlying disease in children with autoimmune diabetes mellitus the expediency of conducting a comprehensive dental examination with subsequent medical observation of doctors of a stomatology profile. In connection with a direct correlation be-tween the degree of activity of caries process and increase the severity of endocrinopathy, treatment and preventive measures in children with autoimmune diabetes should be regularly monitored and conducted with utmost care.