SS-68 IMPACT ON THE CONTRACTIVE ACTIVITY OF ISOLATED VESSELS

Zelenskaya, A. V. and . Bogus, S. K and Suzdalev, K. F. and Galenko-Yaroshevsky, P. A. (2016) SS-68 IMPACT ON THE CONTRACTIVE ACTIVITY OF ISOLATED VESSELS. Kuban Scientific Medical Bulletin, 6 (6). pp. 62-66.

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Abstract

In the experiments on isolated circular segments of the thoracic aorta of a rat it has been proved that indole SS-66 derivative in 10-5 and 10-4 М concentrations can relax smooth muscle cells (SMS) due to its impact on the SMS potassium conduction thus facilitating their hyperpolarization. It results in the block of voltage-sensitive calcium channels, the decrease in calcium input and the SMS relaxing. Lack of the NO-synthase Nω-nitro-L-arginine blocker impact on this process indicates of the lack of the SS-68 impact on the processes connected with the endothelium-dependant SMS relaxation.

Item Type: Article
Subjects: Lib Research Guardians > Medical Science
Depositing User: Unnamed user with email support@lib.researchguardians.com
Date Deposited: 05 Apr 2023 07:58
Last Modified: 07 Aug 2024 06:05
URI: http://eprints.classicrepository.com/id/eprint/657

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