HSV-1/2 Seronegativity and HCV Seropositivity in People Living with HIV Presenting at a Tertiary Care Teaching Hospital in Awka, Anambra State, Nigeria

E. N., Oketah and N., Frank-Peterside and C. R., Elechi and C. H., Ugwu and E. N., Onu and B. J., Okonko (2024) HSV-1/2 Seronegativity and HCV Seropositivity in People Living with HIV Presenting at a Tertiary Care Teaching Hospital in Awka, Anambra State, Nigeria. Asian Journal of Immunology, 7 (1). pp. 21-30.

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Abstract

Herpes simplex virus has public health importance as a leading cause of genital ulcers, which also facilitate human immunodeficiency virus while co-infection with hepatitis C virus and human immunodeficiency virus is common in certain populations. This study was carried out with the aim of determining the prevalence of Herpes simplex virus and hepatitis C virus in people living with HIV attending a teaching hospital in Awka, Anambra State, Nigeria. Blood samples were randomly collected from 100 HIV-infected individuals of which 42 were males and 58 were females and analysed using ELISA. Results showed an overall prevalence of HCV to be 4.0% seropositivity and HSV to be 0.0% with 100.0% seronegativity. Higher prevalence of HCV occurred in ages groups 26-35 years (4.7%) than 16-25 years (4.4%) and 36 years & above (4.0%) with a significant difference of p <0.05. It showed that HCV antibody was only present among females (6.9%) and target not detected (TND) with 4.4%. Higher prevalence of HCV occurred among HIV-infected individuals having CD4 counts of >350 cells/mm3 than the <200 cells/mm3 and 200-249 cells/mm3 (0.0%). The study showed 4.4% seropositivity of HCV and 100.0% seronegativity of HSV in HIV- infected individuals with the highest prevalence of HCV recorded for age boundary 26-35 years. Thus, the increased number of HCV seropositivity among HIV-infected individuals indicates that there is a synergistic relationship between HIV and HCV infection. This study recommends that more attention should be given to the area of HIV/HCV coinfection in the management of infected patients.

Item Type: Article
Subjects: Lib Research Guardians > Medical Science
Depositing User: Unnamed user with email support@lib.researchguardians.com
Date Deposited: 16 Feb 2024 06:37
Last Modified: 20 Jul 2024 05:34
URI: http://eprints.classicrepository.com/id/eprint/2612

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