Biclonal B-Chronic Lymphocytic Leukemia: A rare Case Report with Review of Literature

Shashi, Bansal and Jamil, Syeda Firdos and Amandeep, Talwar and Upendra, Sharma (2021) Biclonal B-Chronic Lymphocytic Leukemia: A rare Case Report with Review of Literature. Asian Hematology Research Journal, 4 (1). pp. 35-39.

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Abstract

Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia is a neoplasm composed of monomorphic small mature B cells that co-express CD5, CD23 and one type of immunoglobulin light chain either kappa or lambda, which is necessary for the diagnosis. Here, we report a case in a 65 year woman with morphological diagnosis of B-Chronic Lymphocytic Leukemia. On flowcytometry analysis, immunoglobulin light chain restriction was not apparent as B cells expressed both kappa & lambda light chains without a clear monotypic population. Sequential gating on flowcytometry revealed two monoclonal B-cell populations and helped in identification of this rare case of biclonal disease in chronic lymphocytic leukemia (CLL).

Item Type: Article
Subjects: Lib Research Guardians > Medical Science
Depositing User: Unnamed user with email support@lib.researchguardians.com
Date Deposited: 02 Feb 2023 12:18
Last Modified: 01 Aug 2024 13:52
URI: http://eprints.classicrepository.com/id/eprint/113

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